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Flurbiprofen General Information

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Flurbiprofen is used to reduce pain, swelling, and joint stiffness from arthritis. Flurbiprofen is known as a nonsteroidal anti-inflammatory drug (NSAID).

If you are treating a chronic condition such as arthritis, ask your doctor about non-drug treatments and/or using other medications to treat your pain. See also Warning section.

Flurbiprofen may also be used to treat arthritis of the spine or gout attacks.

How to Use Flurbiprofen

Read the Medication Guide provided by your pharmacist before you start using Flurbiprofen and each time you get a refill. If you have any questions regarding the information, consult your doctor or pharmacist.

Take Flurbiprofen by mouth with a full glass of water (8 ounces or 240 milliliters), unless your doctor directs you otherwise. Do not lie down for at least 10 minutes after taking Flurbiprofen. If stomach upset occurs while taking Flurbiprofen, take it with food, milk, or an antacid.

Dosage is based on your medical condition and response to therapy. Do not increase your dose or take it more frequently than recommended because this may increase your risk of stomach bleeding. Do not take more than 100 milligrams as a single dose.

It may take up to 2 weeks before the full benefits take effect when Flurbiprofen is taken regularly.

Inform your doctor if your condition worsens.

Flurbiprofen Possible Side Effects

Upset stomach, constipation, diarrhea, gas, heartburn, nausea, vomiting, dizziness, drowsiness, or headache may occur. If any of these effects persist or worsen, notify your doctor or pharmacist promptly.

Remember that your doctor has prescribed Flurbiprofen because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using Flurbiprofen do not have serious side effects.

Flurbiprofen may raise your blood pressure. Check your blood pressure regularly and tell your doctor if the results are high.

Tell your doctor immediately if any of these unlikely but serious side effects occur: stomach pain, swelling of the hands or feet, sudden or unexplained weight gain, vision changes, hearing changes (e.g., ringing in the ears), mental/mood changes, fast/pounding heartbeat, persistent/severe headache, fainting, difficult/painful swallowing, unusual tiredness.

Tell your doctor immediately if any of these rare but very serious side effects occur: change in the amount of urine, easy bruising or bleeding, signs of infection (e.g., fever, persistent sore throat), unexplained stiff neck, slurred speech.

Flurbiprofen may rarely cause serious (possibly fatal) liver disease. If you notice any of the following highly unlikely but very serious side effects, stop taking Flurbiprofen and consult your doctor or pharmacist immediately: yellowing eyes or skin, dark urine, severe stomach/abdominal pain, persistent nausea/vomiting.

A very serious allergic reaction to Flurbiprofen is unlikely, but seek immediate medical attention if it occurs. Symptoms of a serious allergic reaction may include: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

Flurbiprofen Precautions

Before taking Flurbiprofen, tell your doctor or pharmacist if you are allergic to it; or to aspirin or other NSAIDs (e.g., ibuprofen, naproxen, celecoxib); or if you have any other allergies. Flurbiprofen may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Flurbiprofen should not be used if you have certain medical conditions. Before using Flurbiprofen, consult your doctor or pharmacist if you have: aspirin-sensitive asthma (a history of worsening breathing with runny/stuffy nose after taking aspirin or other NSAIDs), recent heart bypass surgery (CABG).

Before using Flurbiprofen, tell your doctor or pharmacist your medical history, especially of: liver disease, poorly controlled diabetes, stomach/intestine/esophagus problems (e.g., bleeding, ulcers, recurring heartburn), heart disease (e.g., history of heart attack), stroke, high blood pressure, swelling (edema, fluid retention), blood disorders (e.g., anemia), bleeding or clotting problems, asthma, growths in the nose (nasal polyps).

Kidney problems can sometimes occur with the use of NSAID medications, including Flurbiprofen. Problems are more likely to occur if you are dehydrated, have heart failure or kidney disease, are an older adult, or if you take certain medications (see also Drug Interactions section). Drink plenty of fluids as directed by your doctor to prevent dehydration and tell your doctor right away if you have any unusual change in the amount of urine.

Before having surgery, tell your doctor or dentist that you are taking Flurbiprofen.

Flurbiprofen may make you dizzy or drowsy. Do not drive, use machinery, or do any activity that requires alertness until you are sure you can perform such activities safely.

Flurbiprofen may cause stomach bleeding. Daily use of alcohol and tobacco, especially when combined with Flurbiprofen, may increase your risk for stomach bleeding. Limit alcohol and stop smoking. Consult your doctor or pharmacist for more information.

Flurbiprofen may make you more sensitive to the sun. Avoid prolonged sun exposure, tanning booths or sunlamps. Use a sunscreen and wear protective clothing when outdoors.

Older adults may be more sensitive to the side effects of Flurbiprofen, especially stomach/intestinal bleeding, kidney problems, and worsening heart problems.

Before using Flurbiprofen, women of childbearing age should talk with their doctor(s) about the benefits and risks (such as miscarriage, trouble getting pregnant). Tell your doctor if you are pregnant or if you plan to become pregnant. During pregnancy, Flurbiprofen should be used only when clearly needed. It is not recommended for use during the first and last trimesters of pregnancy due to possible harm to the unborn baby and interference with normal labor/delivery.

Flurbiprofen passes into breast milk and may have undesirable effects on a nursing infant. Consult your doctor before breast-feeding.

Flurbiprofen Possible Intercations

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.

Some products that may interact with Flurbiprofen include: aliskiren, ACE inhibitors (such as captopril, lisinopril), angiotensin II receptor blockers (such as losartan, valsartan), cidofovir, corticosteroids (e.g., prednisone), lithium, methotrexate, "water pills" (diuretics such as furosemide).

Flurbiprofen may increase the risk of bleeding when taken with other drugs that also may cause bleeding. Examples include anti-platelet drugs such as clopidogrel, "blood thinners" such as dabigatran/enoxaparin/warfarin, among others.

Check all prescription and nonprescription medicine labels carefully since many medications contain pain relievers/fever reducers (aspirin, NSAIDs such as celecoxib, ibuprofen, ketorolac). These drugs are similar to Flurbiprofen and may increase your risk of side effects if taken together. However, if your doctor has directed you to take low-dose aspirin to prevent heart attack or stroke (usually at dosages of 81-325 milligrams a day), you should continue taking the aspirin unless your doctor instructs you otherwise. Ask your doctor or pharmacist for more details.

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